产品货号：
Z20447
中文名称：
MDMX/MDM4抗体
英文名称：
Anti-MDMX/MDM4 Antibody
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MDMX/MDM4 Antibody |
| 指标别名 | Double minute 4 protein;HDMX;Mdm2 like p53 binding protein;MDM4;MDMX;MRP1;p53 binding protein Mdm4;Protein Mdm4;Protein Mdmx |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ELISA |
| 基因名称 | MDM4 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Synthesized peptide derived from human MDMX around the non-phosphorylation site of S367. |
| 计算分子量 | 55KD |
| 成分 | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| 纯化方式 | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | -20℃可保存1年，短期保存或频繁使用请置于4℃，可保存一个月，避免反复冻融。 |
| 背景资料 | Protein Mdm4 is a protein that in humans is encoded by the MDM4 gene.This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus,and shows structural similarity to p53-binding protein MDM2.Both proteins bind the p53 tumor suppressor protein and inhibit its activity,and have been shown to be overexpressed in a variety of human cancers.However,unlike MDM2 which degrades p53,this protein inhibits p53 by binding its transcriptional activation domain.This protein also interacts with MDM2 protein via the RING finger domain,and inhibits the latter's degradation.So this protein can reverse MDM2-targeted degradation of p53,while maintaining suppression of p53 transactivation and apoptotic functions.Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. |
| Uniprot ID | O15151 |
| 基因名全称 | Protein Mdm4 |
| 蛋白名全称 | Protein Mdm4 |
| 推荐稀释比 | WB 1:500～1:2000 IHC 1:100～1:300 ELISA 1:40000 |
相关搜索：MDMX/MDM4抗体，MDMX抗体，MDM4多抗，Anti-MDMX/MDM4 Antibody